Myosin Light Chain Kinase (MLCK, Chicken Gizzard)

Experience the Ocean Advantage by using our Myosin Light Chain Kinase (MLCK). Ocean Biologics has has been a myosin light chain kinase supplier for 26 years. Save valuable time and money by buying our MLCK. We prepare MLCK using proven, gentle, purification methods, and we sell MLCK at competitive prices. So buy MLCK from us!

Myosin-light-chain kinase also known as MYLK or MLCK is a serine/threonine-specific protein kinase that phosphorylates the regulatory light chain of myosin II. Once there is an influx of calcium cations (Ca++) into the muscle, either from the sarcoplasmic reticulum or, more importantly, from the extracellular space, contraction of smooth muscle fibers may begin. First, the calcium will bind to calmodulin. This binding will activate MLCK, which will go on to phosphorylate the myosin light chain at serine residue 19. This will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin (through the crossbridge cycle). Since smooth muscle does not contain a troponin complex like striated muscle does, this mechanism is the main pathway for regulating smooth muscle contraction.